Neurodevelopment After Perinatal Arterial Ischemic Stroke

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Antenatal factors associated with perinatal arterial ischemic stroke.

BACKGROUND AND PURPOSE Perinatal arterial ischemic stroke (PAIS) is a common cause of hemiplegic cerebral palsy in children. The diagnosis of PAIS is based on cerebral imaging. The objective of our study was to determine prenatal risk factors associated with PAIS. METHODS A retrospective case-control study was nested in the whole population of Burgundy, France, from January 2000 to December 2...

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Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke

Based on the review of the literature, perinatal inflammation often induced by infection is the only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS). Preclinical studies show that acute inflammatory processes take place in placenta, cerebral arterial wall of NAIS-susceptible arteries and neonatal brain. A top research priority in NAIS is to further characterize th...

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Perinatal Arterial Ischemic Stroke: An Unusual Causal Mechanism

Perinatal arterial ischemic stroke (AIS) is estimated to occur in 1/1600 to 1/5000 births [1]. Even if rare, it is an important cause of mortality and morbidity in neonates. A meta-analysis showed that 57% of infants who suffer perinatal AIS develop motor and/or cognitive deficits, and 3% die [2]. Risk factors proposed for perinatal AIS include maternal prothrombotic conditions and pre-eclampsi...

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Perinatal ischemic stroke.

Perinatal ischemic stroke is not rare in term and near-term infants and is an important antecedent of long-term neurological disability, including congenital hemiplegia (hemiplegic cerebral palsy) and seizure and cognitive disorders. Changes in maternal hemostasis occur in pregnancy and are amplified in the period immediately surrounding birth; stroke and other thromboembolic events are more fr...

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Risk of Remote Seizures After Perinatal Ischemic Stroke

Investigators from the University of California San Francisco and Kaiser Permanente Medical Centers in Oakland report outcome of perinatal arterial ischemic stroke (PAIS) in a population-based cohort, with particular attention to the incidence of seizures.

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ژورنال

عنوان ژورنال: Pediatrics

سال: 2018

ISSN: 0031-4005,1098-4275

DOI: 10.1542/peds.2017-4164